Polygenetic Determinants of Craniofacial Abnormalities (qtl) Analysis in Mice: Novel Technologies for Searching Enu Large-scale Mutagenesis and Quantitative Trait Linkage
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[PDF] [Full Text] [Abstract] , September 1, 2003; 23 (9): 1501-1509. Arterioscler. Thromb. Vasc. Biol. H. Allayee, A. Ghazalpour and A. J. Lusis Using Mice to Dissect Genetic Factors in Atherosclerosis [PDF] [Full Text] [Abstract] , September 1, 2003; 14 (5): 320-330. Crit. Rev. Oral. Biol. Med. I. Nishimura, T. A. Drake, A. J. Lusis, K. M. Lyons, J. H. Nadeau and J. Zernik POLYGENETIC DETERMINANTS OF CRANIOFACIAL ABNORMALITIES (QTL) ANALYSIS IN MICE: NOVEL TECHNOLOGIES FOR SEARCHING ENU LARGE-SCALE MUTAGENESIS AND QUANTITATIVE TRAIT LINKAGE [PDF] [Full Text] [Abstract] , May 1, 2005; 15 (5): 681-691. Genome Res. S. Doss, E. E. Schadt, T. A. Drake and A. J. Lusis Cis-acting expression quantitative trait loci in mice [PDF] [Full Text] [Abstract] , August 1, 2006; 147 (8): 3915-3923. Endocrinology Rosen Horton, J. Lorenzo, L. R. Donahue, C. Ackert-Bicknell, B. E. Kream, W. G. Beamer and C. J. K. M. Delahunty, K. L. Shultz, G. A. Gronowicz, B. Koczon-Jaremko, M. L. Adamo, L. G. Insulin-Like Growth Factor-I and Bone Acquisition Congenic Mice Provide in Vivo Evidence for a Genetic Locus that Modulates Serum [PDF] [Full Text] [Abstract] , February 1, 2007; 148 (2): 903-911. Endocrinology Shockley, I. R. Reid, A. Grey and C. J. Rosen B. Lecka-Czernik, C. Ackert-Bicknell, M. L. Adamo, V. Marmolejos, G. A. Churchill, K. R. System in Vitro and in Vivo Rosiglitazone Suppresses Components of the Insulin-Like Growth Factor Regulatory Activation of Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) by
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Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease
BACKGROUND Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in organogenesis we conducted a phenotype-driven, genome-wide mutagenesis screen in mice using the mutagen N-ethyl-N-nitrosourea (ENU). ME...
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